Translocation Capture Sequencing: A Method for High Throughput Mapping of Chromosomal Rearrangements

Chromosomal translocations require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are involved in producing leukemias, lymphomas and sarcomas. Translocations are frequent, clonal and recurrent in mature B cell lymphomas, which bear a pa...

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Bibliographic Details
Main Authors: Oliveira, Thiago, Resch, Wolfgang, Jankovic, Mila, Casellas, Rafael, Nussenzweig, Michel C., Klein, Isaac A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285106/
https://ncbi.nlm.nih.gov/pubmed/22033343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2011.10.007
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