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Large Aggregates Are the Major Soluble Aβ Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Soluble amyloid-β (Aβ) aggregates of various sizes, ranging from dimers to large protofibrils, have been associated with neurotoxicity and synaptic dysfunction in Alzheimer's Disease (AD). To investigate the properties of biologically relevant Aβ species, brain extracts from amyloid β protein p...

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Hlavní autoři: Sehlin, Dag, Englund, Hillevi, Simu, Barbro, Karlsson, Mikael, Ingelsson, Martin, Nikolajeff, Fredrik, Lannfelt, Lars, Pettersson, Frida Ekholm
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280222/
https://ncbi.nlm.nih.gov/pubmed/22355408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032014
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