Large Aggregates Are the Major Soluble Aβ Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Soluble amyloid-β (Aβ) aggregates of various sizes, ranging from dimers to large protofibrils, have been associated with neurotoxicity and synaptic dysfunction in Alzheimer's Disease (AD). To investigate the properties of biologically relevant Aβ species, brain extracts from amyloid β protein p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sehlin, Dag, Englund, Hillevi, Simu, Barbro, Karlsson, Mikael, Ingelsson, Martin, Nikolajeff, Fredrik, Lannfelt, Lars, Pettersson, Frida Ekholm
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280222/
https://ncbi.nlm.nih.gov/pubmed/22355408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032014
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