Large Aggregates Are the Major Soluble Aβ Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Soluble amyloid-β (Aβ) aggregates of various sizes, ranging from dimers to large protofibrils, have been associated with neurotoxicity and synaptic dysfunction in Alzheimer's Disease (AD). To investigate the properties of biologically relevant Aβ species, brain extracts from amyloid β protein p...

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Detalhes bibliográficos
Main Authors: Sehlin, Dag, Englund, Hillevi, Simu, Barbro, Karlsson, Mikael, Ingelsson, Martin, Nikolajeff, Fredrik, Lannfelt, Lars, Pettersson, Frida Ekholm
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280222/
https://ncbi.nlm.nih.gov/pubmed/22355408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032014
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