Initial Testing (Stage 1) the Pediatric Preclinical Testing Program of RO4929097, a γ-Secretase Inhibitor Targeting Notch Signaling

RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling. The activity of RO4929097 was evaluated against the in vivo panels of the Pediatric Preclinical Testing Program (PPTP). RO4929097 induced significant differences in event-free sur...

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Autores principales: Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Maris, John M., Lock, Richard, Carol, Hernan, Kurmasheva, Raushan T., Reynolds, C. Patrick, Kang, Min H., Wu, Jianrong, Houghton, Peter J., Smith, Malcolm A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276746/
https://ncbi.nlm.nih.gov/pubmed/22052798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23290
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