Heparin Activates PKR by Inducing Dimerization

Protein kinase R (PKR) is an interferon-induced kinase that plays a pivotal role in the innate immunity pathway. PKR is activated to undergo autophosphorylation upon binding to double-stranded RNAs or RNAs that contain duplex regions. Activated PKR phosphorylates the α subunit of eukaryotic initiati...

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Bibliografske podrobnosti
Main Authors: Anderson, Eric, Pierre-Louis, Willythssa S., Wong, C. Jason, Lary, Jeffrey W., Cole, James L.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268052/
https://ncbi.nlm.nih.gov/pubmed/21978664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.09.025
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