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Activation of PKR by short stem–loop RNAs containing single-stranded arms
Protein kinase R (PKR) is a central component of the innate immunity antiviral pathway and is activated by dsRNA. PKR contains a C-terminal kinase domain and two tandem dsRNA binding domains. In the canonical activation model, binding of multiple PKR monomers to dsRNA enhances dimerization of the ki...
Kaydedildi:
| Yayımlandı: | RNA |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4911914/ https://ncbi.nlm.nih.gov/pubmed/27208315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.053348.115 |
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