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Activation of PKR by short stem–loop RNAs containing single-stranded arms

Protein kinase R (PKR) is a central component of the innate immunity antiviral pathway and is activated by dsRNA. PKR contains a C-terminal kinase domain and two tandem dsRNA binding domains. In the canonical activation model, binding of multiple PKR monomers to dsRNA enhances dimerization of the ki...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:RNA
Egile Nagusiak: Mayo, Christopher B., Wong, C. Jason, Lopez, Prisma E., Lary, Jeffrey W., Cole, James L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911914/
https://ncbi.nlm.nih.gov/pubmed/27208315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.053348.115
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