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Activation of PKR by short stem–loop RNAs containing single-stranded arms

Protein kinase R (PKR) is a central component of the innate immunity antiviral pathway and is activated by dsRNA. PKR contains a C-terminal kinase domain and two tandem dsRNA binding domains. In the canonical activation model, binding of multiple PKR monomers to dsRNA enhances dimerization of the ki...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Mayo, Christopher B., Wong, C. Jason, Lopez, Prisma E., Lary, Jeffrey W., Cole, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911914/
https://ncbi.nlm.nih.gov/pubmed/27208315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.053348.115
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