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Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails

The human RNA-activated protein kinase PKR is an interferon-induced protein that is part of the innate immune response and inhibits viral replication. The action of PKR involves RNA-dependent autophosphorylation leading to inhibition of translation. PKR has an N-terminal dsRNA-binding domain that ca...

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Main Authors: ZHENG, XIAOFENG, BEVILACQUA, PHILIP C.
Formato: Artigo
Idioma:Inglês
Publicado: Copyright 2004 by RNA Society 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370682/
https://ncbi.nlm.nih.gov/pubmed/15547138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7150804
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