Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR.

Myotonic dystrophy is caused by an expanded CTG repeat in the 3' untranslated region of the DM protein kinase (DMPK) gene. The expanded repeat triggers the nuclear retention of mutant DMPK transcripts, but the resulting underexpression of DMPK probably does not fully account for the severe phen...

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Detalhes bibliográficos
Main Authors: Tian, B, White, R J, Xia, T, Welle, S, Turner, D H, Mathews, M B, Thornton, C A
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369895/
https://ncbi.nlm.nih.gov/pubmed/10668800
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