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Mechanism of PKR Activation by dsRNA
PKR (protein kinase R) is a central component of the interferon antiviral defense pathway. Upon binding dsRNA, PKR undergoes autophosphorylation reactions that activate the kinase. PKR then phosphorylates eIF2α, thus inhibiting protein synthesis in virally-infected cells. Here, we define the mechani...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570377/ https://ncbi.nlm.nih.gov/pubmed/18599071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.056 |
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