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Analysis of high affinity binding of PKR to dsRNA

Protein kinase R (PKR) is an interferon-induced kinase which plays a pivotal role in the innate immunity response to viral infection. PKR is activated upon binding to dsRNA. Our previous analysis of PKR binding to dsRNAs ranging from 20-40 bp supports a dimerization model for activation where 30 bp...

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Detalhes bibliográficos
Main Authors: Husain, Bushra, Mukerji, Ishita, Cole, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495235/
https://ncbi.nlm.nih.gov/pubmed/23062027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301226h
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