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Analysis of high affinity binding of PKR to dsRNA
Protein kinase R (PKR) is an interferon-induced kinase which plays a pivotal role in the innate immunity response to viral infection. PKR is activated upon binding to dsRNA. Our previous analysis of PKR binding to dsRNAs ranging from 20-40 bp supports a dimerization model for activation where 30 bp...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3495235/ https://ncbi.nlm.nih.gov/pubmed/23062027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301226h |
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