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Domain interactions in Adenovirus VAI RNA mediate high affinity PKR binding
Protein kinase R (PKR) is a component of the innate immunity antiviral pathway. PKR is activated upon binding to dsRNA to undergo dimerization and autophosphorylation. Adenovirus virus-associated RNA I (VAI) is a short, non-coding transcript whose major function is to inhibit the activity of PKR. VA...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3961479/ https://ncbi.nlm.nih.gov/pubmed/24394721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.12.019 |
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