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RNA Dimerization Promotes PKR Dimerization and Activation
The double-stranded RNA (dsRNA)-activated protein kinase (PKR) plays a major role in the innate immune response in humans. PKR binds dsRNA non-sequence specifically and requires a minimum of 15 bp dsRNA for one protein to bind and 30 bp dsRNA to induce protein dimerization and activation by autophos...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763119/ https://ncbi.nlm.nih.gov/pubmed/19445956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.05.005 |
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