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Activation of PKR by RNA misfolding: HDV ribozyme dimers activate PKR
Protein Kinase R (PKR), the double-stranded RNA (dsRNA)-activated protein kinase, plays important roles in innate immunity. Previous studies have shown that PKR is activated by long stretches of dsRNA, RNA pseudoknots, and certain single-stranded RNAs; however, regulation of PKR by RNAs with globula...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2012
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504668/ https://ncbi.nlm.nih.gov/pubmed/23105000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.034744.112 |
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