Activity of HDV ribozymes to trans-cleave HCV RNA

AIM: To explore whether HDV ribozymes have the ability to trans-cleave HCV RNA. METHODS: Three HDV genomic ribozymes were designed and named RzC1, RzC2 and RzC3. The substrate RNA contained HCV RNA 5’-noncoding region and 5'-fragment of C region (5'-NCR-C). All the ribozymes and HCV RNA 5&...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Yu, Yue-Cheng, Mao, Qing, Gu, Chang-Hai, Li, Qi-Fen, Wang, Yu-Ming
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2002
Subjects:
Viral Hepatitis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656322/
https://ncbi.nlm.nih.gov/pubmed/12174380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v8.i4.694
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