Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development

Hematopoietic stem cells (HSCs) interact with osteoblastic, stromal, and vascular components of the BM hematopoietic microenvironment (HM) that are required for the maintenance of long-term self-renewal in vivo. Osteoblasts have been reported to be a critical cell type making up the HSC niche in viv...

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Detalhes bibliográficos
Main Authors: Lane, Steven W., De Vita, Serena, Alexander, Kylie A., Karaman, Ruchan, Milsom, Michael D., Dorrance, Adrienne M., Purdon, Amy, Louis, Leeann, Bouxsein, Mary L., Williams, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265198/
https://ncbi.nlm.nih.gov/pubmed/22123845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368753
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