TNF Induces Endotoxin Tolerance Mediated by GSK3 in Macrophages

Endotoxin tolerance, a key mechanism for suppressing excessive inflammatory cytokine production and attendant toxicity, is induced by prior exposure of macrophages to TLR ligands. Induction of tolerance by endogenous cytokines has not been investigated. We show that prior exposure to TNF induces a t...

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Bibliographic Details
Main Authors: Park, Sung Ho, Park-Min, Kyung-Hyun, Chen, Janice, Hu, Xiaoyu, Ivashkiv, Lionel B.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258532/
https://ncbi.nlm.nih.gov/pubmed/21602809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2043
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