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IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling
An important mechanism by which IFN-γ primes macrophages for enhanced innate immune responses is abrogation of feedback inhibitory pathways. Accordingly, IFN-γ abrogates endotoxin tolerance, a major negative feedback loop that silences expression of inflammatory cytokine genes in macrophages previou...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2984206/ https://ncbi.nlm.nih.gov/pubmed/20974955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007816107 |
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