TNFα induces sustained signaling and a prolonged and unremitting inflammatory response in synovial fibroblasts

OBJECTIVE: The non resolving character of synovial inflammation in rheumatoid arthritis (RA) is a conundrum. To identify the contribution of fibroblast-like synoviocytes (FLS) to the perpetuation of synovitis, we investigated the molecular mechanisms that govern the TNFα-driven inflammatory program...

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Hlavní autoři: Lee, Angela, Qiao, Yu, Grigoriev, Galina, Chen, Janice, Park-Min, Kyung-Hyun, Park, Sung Ho, Ivashkiv, Lionel B., Kalliolias, George D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618592/
https://ncbi.nlm.nih.gov/pubmed/23335080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37853
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