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The IFN signature and STAT1 expression in RA synovial fluid macrophages are induced by TNFα and counter-regulated by synovial fluid microenvironment

OBJECTIVE: Type I IFNs have emerged as potential activators of the IFN signature and elevated STAT1 expression in RA synovium, but mechanisms that induce synovial IFN expression are unknown. Recently, TNFα was shown to induce a delayed IFN response in macrophages. Thus, we tested whether TNFα, class...

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Hlavní autoři: Gordon, Rachael A., Grigoriev, Galina, Lee, Angela, Kalliolias, George D., Ivashkiv, Lionel B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449023/
https://ncbi.nlm.nih.gov/pubmed/22614743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34544
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