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Prolonged TNFα primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin

OBJECTIVE: During the course of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) are chronically exposed to an inflammatory milieu. In the current study we test the hypothesis that chronic exposure of FLS to TNFα augments inflammatory responses to secondary stimuli (priming effect). METH...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Sohn, Christopher, Lee, Angela, Qiao, Yu, Loupasakis, Konstantinos, Ivashkiv, Lionel B., Kalliolias, George D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455921/
https://ncbi.nlm.nih.gov/pubmed/25199798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38871
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