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Prolonged TNFα primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin
OBJECTIVE: During the course of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) are chronically exposed to an inflammatory milieu. In the current study we test the hypothesis that chronic exposure of FLS to TNFα augments inflammatory responses to secondary stimuli (priming effect). METH...
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| Publicado en: | Arthritis Rheumatol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4455921/ https://ncbi.nlm.nih.gov/pubmed/25199798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38871 |
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