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The cytokine TNF promotes transcription factor SREBP activity and binding to inflammatory genes to activate macrophages and limit tissue repair
Cytokine TNF-mediated macrophage polarization is important for inflammatory disease pathogenesis, but the mechanisms regulating polarization are not clear. We performed transcriptomic and epigenomic analysis of the TNF response in primary human macrophages and reveal late phase activation of SREBP2,...
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| 出版年: | Immunity |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6709581/ https://ncbi.nlm.nih.gov/pubmed/31303399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.06.005 |
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