The cytokine TNF promotes transcription factor SREBP activity and binding to inflammatory genes to activate macrophages and limit tissue repair

Cytokine TNF-mediated macrophage polarization is important for inflammatory disease pathogenesis, but the mechanisms regulating polarization are not clear. We performed transcriptomic and epigenomic analysis of the TNF response in primary human macrophages and reveal late phase activation of SREBP2,...

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Pubblicato in:Immunity
Autori principali: Kusnadi, Anthony, Park, Sung Ho, Yuan, Ruoxi, Pannellini, Tania, Giannopoulou, Eugenia, Oliver, David, Lu, Theresa, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709581/
https://ncbi.nlm.nih.gov/pubmed/31303399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.06.005
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