The cytokine TNF promotes transcription factor SREBP activity and binding to inflammatory genes to activate macrophages and limit tissue repair

Cytokine TNF-mediated macrophage polarization is important for inflammatory disease pathogenesis, but the mechanisms regulating polarization are not clear. We performed transcriptomic and epigenomic analysis of the TNF response in primary human macrophages and reveal late phase activation of SREBP2,...

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Publicado en:Immunity
Main Authors: Kusnadi, Anthony, Park, Sung Ho, Yuan, Ruoxi, Pannellini, Tania, Giannopoulou, Eugenia, Oliver, David, Lu, Theresa, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709581/
https://ncbi.nlm.nih.gov/pubmed/31303399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.06.005
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