Phospholipase D2 (PLD2) Shortens the Time Required for Myeloid Leukemic Cell Differentiation: MECHANISM OF ACTION

Cell differentiation is compromised in acute leukemias. We report that mammalian target of rapamycin (mTOR) and S6 kinase (S6K) are highly expressed in the undifferentiated promyelomonocytic leukemic HL-60 cell line, whereas PLD2 expression is minimal. The expression ratio of PLD2 to mTOR (or to S6K...

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Dades bibliogràfiques
Autors principals: Di Fulvio, Mauricio, Frondorf, Kathleen, Henkels, Karen M., Grunwald, William C., Cool, David, Gomez-Cambronero, Julian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249091/
https://ncbi.nlm.nih.gov/pubmed/22094461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.259465
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