Identification of the Catalytic Site of Phospholipase D2 (PLD2) Newly Described Guanine Nucleotide Exchange Factor Activity

We have demonstrated that phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for Rac2 and determined the PLD2 domains and amino acid site(s) responsible for its GEF activity. Experiments using GST fusion proteins or GST-free counterparts, purified proteins revealed that the PX dom...

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Hlavní autoři: Mahankali, Madhu, Henkels, Karen M., Alter, Gerald, Gomez-Cambronero, Julian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510840/
https://ncbi.nlm.nih.gov/pubmed/23035122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383596
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