TWO SITES OF ACTION FOR PLD2 INHIBITORS: THE ENZYME CATALYTIC CENTER AND AN ALLOSTERIC, PHOSPHOINOSITIDE BINDING POCKET

PLD has been implicated in many physiological functions, such as chemotaxis and phagocytosis, as well as pathological functions, such as cancer cell invasion and metastasis. New inhibitors have been described that hamper the role of PLD in those pathologies but their site of action is not known. We...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Ganesan, Ramya, Mahankali, Madhu, Alter, Gerald, Gomez-Cambronero, Julian
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312721/
https://ncbi.nlm.nih.gov/pubmed/25532944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2014.12.007
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