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Evidence for Two CRIB Domains in Phospholipase D2 (PLD2) That the Enzyme Uses to Specifically Bind to the Small GTPase Rac2

Phospholipase D (PLD) and small GTPases are vital to cell signaling. We report that the Rac2 and the PLD2 isoforms exist in the cell as a lipase-GTPase complex that enables the two proteins to elicit their respective functionalities. A strong association between the two molecules was demonstrated by...

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Detalhes bibliográficos
Main Authors: Peng, Hong-Juan, Henkels, Karen M., Mahankali, Madhu, Dinauer, Mary C., Gomez-Cambronero, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091237/
https://ncbi.nlm.nih.gov/pubmed/21378159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.206672
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