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A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration

Phospholipase D2 (PLD2) is a cell-signaling molecule that bears two activities: a guanine-nucleotide exchange factor (GEF) and a lipase that reside in the PX/PH domains and in two HKD domains, respectively. Upon cell stimulation, the GEF activity yields Rac2-GTP and the lipase activity yields phosph...

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Detalhes bibliográficos
Main Authors: Mahankali, Madhu, Henkels, Karen M., Gomez-Cambronero, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644142/
https://ncbi.nlm.nih.gov/pubmed/23378025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.117960
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