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Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2

We have discovered that the enzyme phospholipase D2 (PLD2) binds directly to the small GTPase Rac2, resulting in PLD2 functioning as a guanine nucleotide exchange factor (GEF), because it switches Rac2 from the GDP-bound to the GTP-bound states. This effect is large enough to be meaningful (∼72% dec...

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Detalhes bibliográficos
Main Authors: Mahankali, Madhu, Peng, Hong-Juan, Henkels, Karen M., Dinauer, Mary C., Gomez-Cambronero, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241757/
https://ncbi.nlm.nih.gov/pubmed/22106281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114692108
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