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The Dual Effect of Rac2 on Phospholipase D2 Regulation That Explains both the Onset and Termination of Chemotaxis

We document a biphasic effect of Rac2 on the activation and inhibition of PLD2. Cells overexpressing Rac2 and PLD2 simultaneously show a robust initial (<10 min) response toward a chemoattractant that is later (>30 min) greatly diminished over PLD2-only controls. The first phase is due to the...

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Detalhes bibliográficos
Main Authors: Peng, Hong-Juan, Henkels, Karen M., Mahankali, Madhu, Marchal, Christophe, Bubulya, Paula, Dinauer, Mary C., Gomez-Cambronero, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133238/
https://ncbi.nlm.nih.gov/pubmed/21444720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01348-10
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