Phospholipase D2 (PLD2) Shortens the Time Required for Myeloid Leukemic Cell Differentiation: MECHANISM OF ACTION

Cell differentiation is compromised in acute leukemias. We report that mammalian target of rapamycin (mTOR) and S6 kinase (S6K) are highly expressed in the undifferentiated promyelomonocytic leukemic HL-60 cell line, whereas PLD2 expression is minimal. The expression ratio of PLD2 to mTOR (or to S6K...

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Detalhes bibliográficos
Main Authors: Di Fulvio, Mauricio, Frondorf, Kathleen, Henkels, Karen M., Grunwald, William C., Cool, David, Gomez-Cambronero, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249091/
https://ncbi.nlm.nih.gov/pubmed/22094461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.259465
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