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The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling, in response to EGF

The adaptor protein Grb2 associates with phospholipase D2 (PLD2), but it is not known if this interaction is necessary for the lipase’s functionality in vivo. In this study, we demonstrate that stable shRNA-based silencing of Grb2, a critical signal transducer of the epidermal growth factor receptor...

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Detalhes bibliográficos
Main Authors: Di Fulvio, Mauricio, Frondorf, Kathleen, Henkels, Karen M., Lehman, Nicholas, Gomez-Cambronero, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1861842/
https://ncbi.nlm.nih.gov/pubmed/17276458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.01.021
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