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Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA Synthesis
Grb2 is an SH2-SH3 protein adaptor responsible for linking growth factor receptors with intracellular signaling cascades. To study the role of Grb2 in cell growth, we have generated a new COS7 cell line (COS7(shGrb2)), based on RNAi technology, as null mutations in mammalian Grb2 genes are lethal in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2247433/ https://ncbi.nlm.nih.gov/pubmed/17445773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.04.013 |
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