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The Vitamin K-dependent Carboxylase Generates γ-Carboxylated Glutamates by Using CO(2) to Facilitate Glutamate Deprotonation in a Concerted Mechanism That Drives Catalysis

The γ-glutamyl carboxylase converts Glu to carboxylated Glu (Gla) to activate a large number of vitamin K-dependent proteins with diverse functions, and this broad physiological impact makes it critical to understand the mechanism of carboxylation. Gla formation is thought to occur in two independen...

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Hlavní autoři: Rishavy, Mark A., Hallgren, Kevin W., Berkner, Kathleen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248010/
https://ncbi.nlm.nih.gov/pubmed/21896484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249177
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