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Vitamin K Oxygenation, Glutamate Carboxylation, and Processivity: Defining the Three Critical Facets of Catalysis by the Vitamin K–Dependent Carboxylase

The vitamin K–dependent carboxylase uses vitamin K oxygenation to drive carboxylation of multiple glutamates in vitamin K–dependent proteins, rendering them active in a variety of physiologies. Multiple carboxylations of proteins are required for their activity, and the carboxylase is processive, so...

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Detalhes bibliográficos
Main Authors: Rishavy, Mark A., Berkner, Kathleen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Nutrition 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648714/
https://ncbi.nlm.nih.gov/pubmed/22516721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/an.111.001719
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