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Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of His160 disrupts Glu carbanion formation and the efficient coupling of vitamin K epoxidation to Glu carboxylation
Vitamin K-dependent (VKD) proteins become activated by the VKD carboxylase, which converts Glu’s to carboxylated Glu’s (Gla’s) in their Gla domains. The carboxylase uses vitamin K epoxidation to drive Glu carboxylation, and the two half-reactions are coupled in 1:1 stoichiometry by an unknown mechan...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293503/ https://ncbi.nlm.nih.gov/pubmed/18717596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800296r |
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