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Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of His160 disrupts Glu carbanion formation and the efficient coupling of vitamin K epoxidation to Glu carboxylation

Vitamin K-dependent (VKD) proteins become activated by the VKD carboxylase, which converts Glu’s to carboxylated Glu’s (Gla’s) in their Gla domains. The carboxylase uses vitamin K epoxidation to drive Glu carboxylation, and the two half-reactions are coupled in 1:1 stoichiometry by an unknown mechan...

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Bibliografske podrobnosti
Main Authors: Rishavy, Mark A., Berkner, Kathleen L.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293503/
https://ncbi.nlm.nih.gov/pubmed/18717596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800296r
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