Wird geladen...

Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of His160 disrupts Glu carbanion formation and the efficient coupling of vitamin K epoxidation to Glu carboxylation

Vitamin K-dependent (VKD) proteins become activated by the VKD carboxylase, which converts Glu’s to carboxylated Glu’s (Gla’s) in their Gla domains. The carboxylase uses vitamin K epoxidation to drive Glu carboxylation, and the two half-reactions are coupled in 1:1 stoichiometry by an unknown mechan...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Rishavy, Mark A., Berkner, Kathleen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293503/
https://ncbi.nlm.nih.gov/pubmed/18717596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800296r
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!