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The Vitamin K-dependent Carboxylase Generates γ-Carboxylated Glutamates by Using CO(2) to Facilitate Glutamate Deprotonation in a Concerted Mechanism That Drives Catalysis
The γ-glutamyl carboxylase converts Glu to carboxylated Glu (Gla) to activate a large number of vitamin K-dependent proteins with diverse functions, and this broad physiological impact makes it critical to understand the mechanism of carboxylation. Gla formation is thought to occur in two independen...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248010/ https://ncbi.nlm.nih.gov/pubmed/21896484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249177 |
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