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A new model for vitamin K-dependent carboxylation: The catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine

Vitamin K-dependent (VKD) proteins require carboxylation for diverse functions that include hemostasis, apoptosis, and Ca(2+) homeostasis, yet the mechanism of carboxylation is not well understood. Combined biochemical and chemical studies have led to a long-standing model in which a carboxylase Cys...

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Главные авторы: Rishavy, Mark A., Pudota, B. Nirmala, Hallgren, Kevin W., Qian, Wen, Yakubenko, Anna V., Song, Jee-Hyeon, Runge, Kurt W., Berkner, Kathleen L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC518825/
https://ncbi.nlm.nih.gov/pubmed/15365175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404989101
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