A new model for vitamin K-dependent carboxylation: The catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine

Vitamin K-dependent (VKD) proteins require carboxylation for diverse functions that include hemostasis, apoptosis, and Ca(2+) homeostasis, yet the mechanism of carboxylation is not well understood. Combined biochemical and chemical studies have led to a long-standing model in which a carboxylase Cys...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Rishavy, Mark A., Pudota, B. Nirmala, Hallgren, Kevin W., Qian, Wen, Yakubenko, Anna V., Song, Jee-Hyeon, Runge, Kurt W., Berkner, Kathleen L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC518825/
https://ncbi.nlm.nih.gov/pubmed/15365175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404989101
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados