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Novel Insight into the Mechanism of the Vitamin K Oxidoreductase (VKOR): ELECTRON RELAY THROUGH Cys(43) AND Cys(51) REDUCES VKOR TO ALLOW VITAMIN K REDUCTION AND FACILITATION OF VITAMIN K-DEPENDENT PROTEIN CARBOXYLATION
The vitamin K oxidoreductase (VKOR) reduces vitamin K to support the carboxylation and consequent activation of vitamin K-dependent proteins, but the mechanism of reduction is poorly understood. VKOR is an integral membrane protein that reduces vitamin K using membrane-embedded thiols (Cys-132 and C...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044983/ https://ncbi.nlm.nih.gov/pubmed/20978134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172213 |
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