Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation

The vitamin K-dependent carboxylase modifies and renders active vitamin K-dependent proteins involved in hemostasis, cell growth control, and calcium homeostasis. Using a novel mechanism, the carboxylase transduces the free energy of vitamin K hydroquinone (KH(2)) oxygenation to convert glutamate in...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pudota, B. Nirmala, Miyagi, Masaru, Hallgren, Kevin W., West, Karen A., Crabb, John W., Misono, Kunio S., Berkner, Kathleen L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27173/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087858/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.24.13033
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