Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation

The vitamin K-dependent carboxylase modifies and renders active vitamin K-dependent proteins involved in hemostasis, cell growth control, and calcium homeostasis. Using a novel mechanism, the carboxylase transduces the free energy of vitamin K hydroquinone (KH(2)) oxygenation to convert glutamate in...

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Main Authors: Pudota, B. Nirmala, Miyagi, Masaru, Hallgren, Kevin W., West, Karen A., Crabb, John W., Misono, Kunio S., Berkner, Kathleen L.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC27173/
https://ncbi.nlm.nih.gov/pubmed/11087858
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