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Methylation of gamma-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the gamma-glutamyl carboxylase

Gamma-carboxylated Glu (Gla) is a post-translational modification required for the activity of vitamin K-dependent (VKD) proteins that has been difficult to study by mass spectrometry due to the properties of this negatively-charged residue. Gla is generated by a single enzyme, the gamma-glutamyl ca...

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Bibliografiske detaljer
Main Authors: Hallgren, K. W., Zhang, D., Kinter, M., Willard, B., Berkner, K. L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676713/
https://ncbi.nlm.nih.gov/pubmed/22536908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr3003722
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