The Vitamin K-dependent Carboxylase Generates γ-Carboxylated Glutamates by Using CO(2) to Facilitate Glutamate Deprotonation in a Concerted Mechanism That Drives Catalysis

Antzeko izenburuak

• Vitamin K Oxygenation, Glutamate Carboxylation, and Processivity: Defining the Three Critical Facets of Catalysis by the Vitamin K–Dependent Carboxylase
  nork: Rishavy, Mark A., et al.
  Argitaratua: (2012)
• Novel Insight into the Mechanism of the Vitamin K Oxidoreductase (VKOR): ELECTRON RELAY THROUGH Cys(43) AND Cys(51) REDUCES VKOR TO ALLOW VITAMIN K REDUCTION AND FACILITATION OF VITAMIN K-DEPENDENT PROTEIN CARBOXYLATION
  nork: Rishavy, Mark A., et al.
  Argitaratua: (2011)
• Vitamin K-dependent carboxylation of the carboxylase
  nork: Berkner, Kathleen L., et al.
  Argitaratua: (1998)
• Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of His160 disrupts Glu carbanion formation and the efficient coupling of vitamin K epoxidation to Glu carboxylation
  nork: Rishavy, Mark A., et al.
  Argitaratua: (2008)
• A new model for vitamin K-dependent carboxylation: The catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine
  nork: Rishavy, Mark A., et al.
  Argitaratua: (2004)