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Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

Lymphodepletion prior to adoptive cell transfer (ACT)-based immunotherapies can enhance anti-tumor responses by augmenting innate immunity, by increasing access to homeostatic cytokines, and by depressing the numbers of regulatory T cells and myeloid-derived suppressor cells. Although it is clear th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wrzesinski, Claudia, Paulos, Chrystal M., Kaiser, Andrew, Muranski, Pawel, Palmer, Douglas C., Gattinoni, Luca, Yu, Zhiya, Rosenberg, Steven A., Restifo, Nicholas P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247626/
https://ncbi.nlm.nih.gov/pubmed/19952961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181b88ffc
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