In Vivo Sustained Release of siRNA from Solid Lipid Nanoparticles

Small interfering RNA (siRNA) is a highly potent drug in gene-based therapy with a challenge of being delivered in a sustained manner. Nanoparticle drug delivery systems allow for incorporating and controlled release of therapeutic payloads. We demonstrate that solid lipid nanoparticles can incorpor...

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Huvudupphovsmän: Lobovkina, Tatsiana, Jacobson, Gunilla B., Gonzalez, Emilio Gonzalez, Hickerson, Robyn P., Leake, Devin, Kaspar, Roger L., Contag, Christopher H., Zare, Richard N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246574/
https://ncbi.nlm.nih.gov/pubmed/22077198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn203745n
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