Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells

The polyanionic nature of oligonucleotides and their enzymatic degradation present challenges for the use of siRNA in research and therapy; among the most notable of these is clinically relevant delivery into cells. To address this problem, we designed and synthesized the first members of a new clas...

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Bibliografiske detaljer
Main Authors: Geihe, Erika I., Cooley, Christina B., Simon, Jeff R., Kiesewetter, Matthew K., Edward, Justin A., Hickerson, Robyn P., Kaspar, Roger L., Hedrick, James L., Waymouth, Robert M., Wender, Paul A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421195/
https://ncbi.nlm.nih.gov/pubmed/22847412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211361109
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