Stability Study of Unmodified siRNA and Relevance to Clinical Use

RNA interference offers enormous potential to develop therapeutic agents for a variety of diseases. To assess the stability of siRNAs under conditions relevant to clinical use with particular emphasis on topical delivery considerations, a study of three different unmodified siRNAs was performed. The...

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Detalhes bibliográficos
Main Authors: Hickerson, Robyn P., Vlassov, Alexander V., Wang, Qian, Leake, Devin, Ilves, Heini, Gonzalez-Gonzalez, Emilio, Contag, Christopher H., Johnston, Brian H., Kaspar, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2008
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829675/
https://ncbi.nlm.nih.gov/pubmed/18844576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/oli.2008.0149
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