Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD)

Despite rapid progress in the development of potent and selective small interfering RNA (siRNA) agents for skin disorders, translation to the clinic has been hampered by the lack of effective, patient-friendly delivery technologies. The stratum corneum poses a formidable barrier to efficient deliver...

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Main Authors: Gonzalez-Gonzalez, Emilio, Speaker, Tycho J, Hickerson, Robyn P, Spitler, Ryan, Flores, Manuel A, Leake, Devin, Contag, Christopher H, Kaspar, Roger L
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2010
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956931/
https://ncbi.nlm.nih.gov/pubmed/20571543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.126
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