Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD)

Despite rapid progress in the development of potent and selective small interfering RNA (siRNA) agents for skin disorders, translation to the clinic has been hampered by the lack of effective, patient-friendly delivery technologies. The stratum corneum poses a formidable barrier to efficient deliver...

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Detalhes bibliográficos
Main Authors: Gonzalez-Gonzalez, Emilio, Speaker, Tycho J, Hickerson, Robyn P, Spitler, Ryan, Flores, Manuel A, Leake, Devin, Contag, Christopher H, Kaspar, Roger L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956931/
https://ncbi.nlm.nih.gov/pubmed/20571543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.126
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