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Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD)

Despite rapid progress in the development of potent and selective small interfering RNA (siRNA) agents for skin disorders, translation to the clinic has been hampered by the lack of effective, patient-friendly delivery technologies. The stratum corneum poses a formidable barrier to efficient deliver...

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Autors principals: Gonzalez-Gonzalez, Emilio, Speaker, Tycho J, Hickerson, Robyn P, Spitler, Ryan, Flores, Manuel A, Leake, Devin, Contag, Christopher H, Kaspar, Roger L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956931/
https://ncbi.nlm.nih.gov/pubmed/20571543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.126
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