Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device

Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis. Although hypodermic needles can be used to transpor...

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Détails bibliographiques
Auteurs principaux: Hickerson, Robyn P, Wey, Winston C, Rimm, David L, Speaker, Tycho, Suh, Susie, Flores, Manuel A, Gonzalez-Gonzalez, Emilio, Leake, Devin, Contag, Christopher H, Kaspar, Roger L
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027428/
https://ncbi.nlm.nih.gov/pubmed/24150576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.56
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