Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device

Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis. Although hypodermic needles can be used to transpor...

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Bibliografiske detaljer
Main Authors: Hickerson, Robyn P, Wey, Winston C, Rimm, David L, Speaker, Tycho, Suh, Susie, Flores, Manuel A, Gonzalez-Gonzalez, Emilio, Leake, Devin, Contag, Christopher H, Kaspar, Roger L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027428/
https://ncbi.nlm.nih.gov/pubmed/24150576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.56
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