Inhibition of CD44 Gene Expression in Human Skin Models, Using Self-Delivery Short Interfering RNA Administered by Dissolvable Microneedle Arrays

Treatment of skin disorders with short interfering RNA (siRNA)-based therapeutics requires the development of effective delivery methodologies that reach target cells in affected tissues. Successful delivery of functional siRNA to the epidermis requires (1) crossing the stratum corneum, (2) transfer...

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Detalhes bibliográficos
Main Authors: Lara, Maria Fernanda, González-González, Emilio, Speaker, Tycho J., Hickerson, Robyn P., Leake, Devin, Milstone, Leonard M., Contag, Christopher H., Kaspar, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413896/
https://ncbi.nlm.nih.gov/pubmed/22480249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.211
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